Is there a female protagonist in GTA 6?
Yes. Lucia Caminos is a confirmed playable protagonist — the first playable female lead in a modern mainline GTA game.
Lucia is introduced as fresh out of Leonida Penitentiary after taking the fall to protect her family, forming one half of GTA 6’s crime-couple duo alongside Jason Duval. She’s been a central figure in both official trailers, not a secondary or optional character.
GTA 5’s three protagonists (Michael, Franklin, Trevor) were all male, making Lucia’s confirmed role a notable first for the mainline series in its HD-era and beyond.